Atrazine 101: Everything Farmers Need to Know About Atrazine

FBN Network

Jul 17, 2024

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This guide includes the following sections:

What Is Atrazine?

Atrazine is a selective, systemic herbicide that offers pre- and post-emergence control of grass and broadleaf weeds in row crops, including corn, sugarcane, and sorghum. It has been used extensively in corn production in the United States since the 1960s. Today, according to USDA National Agricultural Statistics Service, it’s applied to more than 60% of all U.S. corn acres. 

It’s become one of corn's most widely used herbicides because it is highly efficacious and relatively affordable. Some atrazine herbicides are labeled for use on wheat, macadamia nuts, and guava, as well as for non-agricultural uses such as managing roadsides, ornamentals, and turf. Atrazine is also a widely recommended tank mix partner for other corn herbicides.

How Does Atrazine Work?

Atrazine is a Group 5 photosynthesis inhibitor herbicide in the triazine family, which also includes the active ingredients prometryn and simazine. It controls weeds by inhibiting the function of the Photosystem II complex, reducing photosynthesis rates, and diminishing plant growth. 

How Long Does Atrazine Take to Work?

Atrazine is a systemic herbicide that is taken up by a weed’s roots and transported to actively growing plant tissue. It causes severe oxidative damage to a weed’s proteins, lipids, and pigments, eventually resulting in cell membrane destruction and plant death. Atrazine is a relatively slow-working herbicide; visible plant effects may not appear until 14 to 21 days after an application and often include a gradual wilting and drying out of the weed. 

Variables affecting how quickly atrazine is taken up and translocated throughout the target weed can include: 

  • Temperature

  • Relative humidity

  • Rainfall following application

  • Soil moisture

  • Plant stress 

  • Light availability 

Atrazine Application Best Practices

As a systemic herbicide, atrazine is most effective under conditions that favor healthy plant growth. While it does have some foliar activity, atrazine is often tank-mixed with common contact herbicides for more effective control of emerged weeds in pre-plant applications. 

Atrazine can be applied pre-plant, at-plant, or post-emergence in corn and sorghum. 

Atrazine is a restricted-use pesticide, and runoff is a concern, especially near sensitive environmental areas and bodies of water. To reduce the risk of runoff and surface water contamination, follow label instructions and best application practices to protect waterways. 

Atrazine application rates will vary depending on the:

  • Product

  • Application timing

  • Soil type

  • Tillage method 

  • Crop

  • Targeted weed species 

  • Environmental conditions

Typical rates for GCS Atrazine 4L* in corn are:

Current atrazine label requirements for corn and grain sorghum impose an application limit of 2.5 pounds of active ingredient per acre (lb. ai/A) per calendar year. Additionally, there is a per-application maximum of no more than 1.6 or 2 lb. ai/A depending on soil erodibility and the amount of crop residue cover. These limits are cumulative for all products, including premixes, that may contain atrazine as an active ingredient. Consult specific product labels for recommended application rates. 

How to Tank Mix with Atrazine

Some weeds resistant to glyphosate are sensitive to atrazine, making it an excellent tank mix partner in any corn weed control program. It is compatible with many common corn herbicides and is included in many premix products.  

Common tank mix partners for GCS Atrazine 4L include:

  • metolachlor*** 

  • metolachlor + paraquat*

  • metolachlor + glyphosate

  • metolachlor + simazine

  • metolachlor + simazine + paraquat

  • metolachlor + simazine + glyphosate 

  • propachlor

  • alachlor

  • alachlor + glyphosate

  • alachlor + paraquat

  • paraquat

  • simazine

  • simazine + paraquat 

  • simazine + glyphosate

  • glyphosate 

  • butylate

***Includes metolachlor and s-metolachlor

An emulsifiable oil or oil concentrate is recommended to enhance atrazine efficacy, especially for post-emergence, water-based applications. 

Atrazine Label Updates

The United States Environmental Protection Agency (US EPA) is reviewing atrazine’s registration, which could change the allowable maximum use rates in coming seasons. Additionally, it could fall under new requirements associated with enforcing the Endangered Species Act, which may add more application restrictions. Consult with your local agronomist for the latest atrazine label updates.    


Are you spray compliant? Find out what farmers need to know about the proposed EPA herbicide label updates in this FBN blog.


Atrazine Resistance Management

Atrazine has been widely used in row crop production for decades, making it a vulnerable target for developing herbicide resistance. The International Herbicide-Resistant Weed Database reports that 66 weed species are resistant to atrazine worldwide as of 2024. Atrazine-resistant waterhemp and Palmer amaranth populations have expanded throughout corn-growing geographies in recent years, making the herbicide less effective on these troublesome weeds.

Use these tips to reduce your risk of developing atrazine-resistant weed populations.

  • Make timely herbicide applications when weeds are 4” or smaller 

  • Use multiple modes and sites of action

  • Employ crop rotation to diversify herbicides

  • Use layered residuals to extend the window of weed control

  • Add effective adjuvants to improve spray performance and plant uptake

  • Scout fields after applications to verify the application was effective

  • Add cultural or mechanical weed control practices, including tillage where appropriate


Learn how to manage 5,000 pests through the FBN Pest Solutions pages.


Atrazine Human and Environmental Safety Guidelines

While atrazine is relatively safe from a human toxicity standpoint, applicators should still use best safety practices when using the product. 

  • Do not enter treated areas during the 12-hour restricted entry interval (REI) or until the spray solution has dried. 

  • When handling atrazine, wear appropriate personal protective equipment (PPE), including a long shirt, pants, and close-toed shoes. 

  • Wash your hands after handling the herbicide and remove clothing and PPE immediately if the product gets inside. 

  • Follow all label instructions to ensure the safe use of atrazine.

Atrazine is toxic to aquatic invertebrates, so proper precautions must be taken when applying it to fields near sensitive environmental areas. This includes:

  • Avoid applying directly to water, areas where water is present, or intertidal areas below the mean high-water mark.

  • Avoid applications when weather conditions favor drift from treated areas. Runoff and drift from treated areas may be hazardous to aquatic organisms in neighboring areas.

  • Be mindful of residual chemical contamination when disposing of equipment washwaters or rinsate.

Buy Atrazine from FBN 

Whether you prefer to customize an atrazine tank mix or apply a premixed herbicide, FBN has you covered: 

Combine GCS Atrazine 4L* with Willowood Paraquat 3SL or Willowood Glypho 5 for effective broad-spectrum weed control. 

Or, choose a premix like Fearless Xtra 5.6L* (acetochlor + atrazine) or MesoXtra Herbicide* (atrazine + mesotrione + metolachlor) for added convenience. 

For a complete weed control solution, add label-required adjuvants like IN-Plant™ Crop Oil Concentrate (COC) for even more cost savings. 

With a convenient online platform, transparent pricing, and direct-to-farm delivery available on your schedule, FBN puts Farmers First®. 


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GCS Atrazine 4L is a restricted use pesticide.

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FBN Network

Jul 17, 2024

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